PLX-4545 | IKZF2 degrader | Probechem Biochemicals

Chemical Structure : PLX-4545

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PLX-4545 (PLX4545)

货号: PC-24555Not For Human Use, Lab Use Only.

PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity.

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生物&药学活性

PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity.
Oral administration of PLX-4545 resulted in dose dependent depletion of IKZF2 and single agent antitumor activity in vivo.
PLX-4545 treatment preferentially converted tumor Tregs into effector-like T-cells through decreased CD25 expression and increased production of effector cytokines (IL2, IFNγ), resulting in increased infiltration of CD4/8 Teff cells into tumor tissue.
Combination of PLX-4545 with anti-PD1 significantly increased the proliferation of Teff cells and inhibition of tumor growth in vivo.

物理化学性质&存储条件

分子量	473.57
分子式	C28H31N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(1-oxo-5-(((1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Yujun Huang, et al. Cancer Res (2025) 85 (8_Supplement_1): 6380.

2. Chen Z, et al. Nat Commun. 2025 May 1;16(1):4095.

PLX-4545 (PLX4545)

生物&药学活性

物理化学性质&存储条件

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PLX-4545 (PLX4545)

生物&药学活性

物理化学性质&存储条件

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