| Cat. No. |
Product Name |
Information |
| PC-60121 |
SNIPER(ABL)-062
BCR-ABL degrader
|
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation. |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-28804 |
LRG20
GLI1 degrader
|
LRG20 is a potent, orally bioavailable, CRBN-dependent GLI1 PROTAC degrader with DC50 of 16.93 nM and Dmax=91.1% in HT-29 colorectal cancer cells, preferentially degrading GLI1/GLI2 over GLI3 without obvious degradation of representative CRBN neo-substrates. |
| PC-28783 |
AF151
METTL3 PROTAC
|
AF151 is a potent, efficient, VHL-based METTL3 PROTAC degrader with DC50 of 430 nM in AML cell line MOLM-13, Dmax=95%. |
| PC-28735 |
SN38-PROTAC
RPL15 degrader
|
SN38-PROTAC (SN38-(PEG)2-Pom-α) is a selective RPL15 PROTAC degrader, induces ubiquitin-mediated degradation of RPL15. |
| PC-28724 |
RNK06138
ERK5 degrader
|
RNK06138 is a potent, tumor-selective, and efficacious chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, CHAMP), binds HSP90 with IC50 of 306 nM, inhibits ERK5 kinase activity with IC50 of 615 nM, decreases ERK5 protein levels with Dmax of 74% and DC50 of 111.7 nM in MOLP-8 myeloma cell line. |
