BETd-260 trifluoroacetate | BET PROTAC | Probechem Biochemicals

Chemical Structure : BETd-260 trifluoroacetate

CAS No.: 2140289-21-8

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BETd-260 trifluoroacetate (ZBC260, BETd260 TFA)

货号: PC-60103Not For Human Use, Lab Use Only.

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

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1 mg	￥1980	In stock
5 mg	￥3580	In stock
10 mg	￥5880	In stock
25 mg		Get quote

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生物&药学活性

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.
BETd-260 effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth.
BETd-260 induces rapid tumor regression in vivo against RS4;11 xenograft tumors.

物理化学性质&存储条件

分子量	912.928
分子式	C45H47F3N10O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino)-7-(3,5-dimethylisoxazol-4-yl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide 2,2,2-trifluoroacetate

参考文献

1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816.

BETd-260 trifluoroacetate (ZBC260, BETd260 TFA)

生物&药学活性

物理化学性质&存储条件

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BETd-260 trifluoroacetate (ZBC260, BETd260 TFA)

生物&药学活性

物理化学性质&存储条件

参考文献

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