SN38-PROTAC | RPL15 degrader | Probechem Biochemicals

Chemical Structure : SN38-PROTAC

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SN38-PROTAC (SN38-(PEG)2-Pom-α)

货号: PC-28735Not For Human Use, Lab Use Only.

SN38-PROTAC (SN38-(PEG)2-Pom-α) is a selective RPL15 PROTAC degrader, induces ubiquitin-mediated degradation of RPL15.

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100 mg		Get quote

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生物&药学活性

SN38-PROTAC (SN38-(PEG)2-Pom-α) is a selective RPL15 PROTAC degrader, induces ubiquitin-mediated degradation of RPL15.
SN38-PROTAC selectively decreases nuclear RPL15 protein levels via a post-translational mechanism.
SN38-PROTAC promotes RPL15 ubiquitination and its degradation, dependent on CRBN.
SN38-PROTAC induces RPL15 ubiquitination and JNK-dependent DAMP secretion from cancer cells.
SN38-PROTAC enhances the sensitivity of B16-F10 tumors to anti-PD-1 antibody, dependent on human CRBN expression.
SN38-PROTAC activates STING-mediated antitumor immune responses.

物理化学性质&存储条件

分子量	918.92
分子式	C46H46N8O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(2-(2-(4-((((S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide

参考文献

1. Takahashi R, et al. Oncogene. 2025 Dec;44(50):4846-4854.

SN38-PROTAC (SN38-(PEG)2-Pom-α)

生物&药学活性

物理化学性质&存储条件

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SN38-PROTAC (SN38-(PEG)2-Pom-α)

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物理化学性质&存储条件

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