SNIPER(ABL)-062 | BCR-ABL degrader | Probechem Biochemicals

Chemical Structure : SNIPER(ABL)-062

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SNIPER(ABL)-062 (SNIPER ABL 062)

货号: PC-60121Not For Human Use, Lab Use Only.

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.

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生物&药学活性

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
SNIPER(ABL)-062 shows desirable binding affinities against ABL1, cIAP1/2, and XIAP (IC50=80-500 nM).
SNIPER(ABL)-062 inhibits BCR-ABL-mediated signaling pathways and CML proliferation in cells expressing BCR-ABL.

物理化学性质&存储条件

分子量	1089.655
分子式	C53H63ClF2N10O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-((2-(2-(2-(3-(2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethyl)carbamoyl)pyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide

参考文献

1. Shimokawa K, et al. ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047.

SNIPER(ABL)-062 (SNIPER ABL 062)

生物&药学活性

物理化学性质&存储条件

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SNIPER(ABL)-062 (SNIPER ABL 062)

生物&药学活性

物理化学性质&存储条件

参考文献

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