ARV-771 (ARV771) | BET PROTAC | Probechem Biochemicals

Chemical Structure : ARV-771

CAS No.: 1949837-12-0

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ARV-771 (ARV 771, ARV771)

货号: PC-42297Not For Human Use, Lab Use Only.

ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.
ARV-771 is equally potent activity in VCaP and LnCaP95 CRPC cell lines, causes depletion of c-MYC with IC50<1 nM.
ARV-771 suppresses both AR signaling and AR levels and leads to tumor regression in a CRPC mouse xenograft model.

物理化学性质&存储条件

分子量	986.6398
分子式	C49H60ClN9O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-c

参考文献

1. Raina K, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.

2. Saenz DT, et al. Leukemia. 2017 Jan 31. doi: 10.1038/leu.2016.393.

ARV-771 (ARV 771, ARV771)

生物&药学活性

物理化学性质&存储条件

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ARV-771 (ARV 771, ARV771)

生物&药学活性

物理化学性质&存储条件

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