PDCD2 degrader 10e

Chemical Structure : PDCD2 degrader 10e

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货号: PC-21116Not For Human Use, Lab Use Only.

PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PDCD2 degrader 10e induces a concentration-dependent G2/M phase arrest, effectively inhibits the cell cycle progression in MOLT-4 cells.
PDCD2 degrader 10e displays a significant reduction of PDCD2 in MOLT-4 cells, but does not significantly impede cell viability.
PDCD2 degrader 10e is a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts.
Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis.

物理化学性质&存储条件

分子量	832.84
分子式	C45H39F3N6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S)-1-(6-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4- yl)oxy)acetyl)piperidin-4-yl)amino)pyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2- naphthamide

参考文献

1. Wenzhi Ji, et al. Angew Chem Int Ed Engl. 2023 Sep 1;e202308292.