DBr-1 | DCAF1-BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : DBr-1

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DBr-1 (DCAF1-BRD9 PROTAC)

货号: PC-21642Not For Human Use, Lab Use Only.

DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder.
DBr-1 shows a similar degradation preference as the CRBN-based PROTAC dBRD9, only strongly affecting BRD9 but unlike the VZ185 not BRD7 levels.
DBr-1 potently degrades BRD9 with a DC50 of 90 nM but only weakly affected BRD7 protein levels in HEK293/BRD9-HiBiT and HEK293/BRD7-HiBiT cells, respectively.

物理化学性质&存储条件

分子量	970.66
分子式	C55H68ClN9O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((4-((6-(4-(4-((2-aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)-6-oxohexyl)oxy)piperidin-1-yl)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

参考文献

1. Schröder M, et al. Nat Commun. 2024 Jan 4;15(1):275.