TKP-5

Chemical Structure : TKP-5

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货号: PC-26534Not For Human Use, Lab Use Only.

TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression.

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生物&药学活性

TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression.

物理化学性质&存储条件

分子量	833.90
分子式	C44H47N7O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-(4-((4-(3-(2-(2-Acetamidoethyl)-5-ethoxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

参考文献

1. Hiroyuki Yamakoshi, et al. J Med Chem. 2026 Apr 9;69(7):8388-8416.

TKP-5

生物&药学活性

物理化学性质&存储条件

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TKP-5

生物&药学活性

物理化学性质&存储条件

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