UBX-382 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : UBX-382

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UBX-382 (UBX382)

货号: PC-49392Not For Human Use, Lab Use Only.

UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.

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100 mg		Get quote

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生物&药学活性

UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
UBX-382 efficiently inhibits MEK and ERK signaling in B-cell lymphoma.
UBX-382 degrades various mutant BTK proteins in vitro and in vivo, UBX-382 significantly inhibits cell proliferation in cell lines including C481S mutant.
UBX-382 inhibits hematological cell line proliferation via CRBN dependency.

物理化学性质&存储条件

分子量	752.880
分子式	C42H44N10O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-((7-((3-((2,6-dimethylphenyl)amino)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Ye Seul Lim, et al. Blood Adv. 2022 Oct 21;bloodadvances.2022008121.

UBX-382 (UBX382)

生物&药学活性

物理化学性质&存储条件

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UBX-382 (UBX382)

生物&药学活性

物理化学性质&存储条件

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