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首页-抗体药物偶连体和PROTACs-PROTAC-SJPYT-195
SJPYT-195

Chemical Structure : SJPYT-195

CAS No.: 2973762-16-0

SJPYT-195 (SJPYT195)

货号: PC-49310Not For Human Use, Lab Use Only.

SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligand of the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

    物理化学性质&存储条件

    分子量 666.691
    分子式 C35H34N6O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3-(tert-butyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

    参考文献

    1. Andrew D Huber, et al. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320.

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