YSA64 | RBM39 degrader | Probechem Biochemicals

Chemical Structure : YSA64

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YSA64 (YSA-64)

货号: PC-28648Not For Human Use, Lab Use Only.

YSA64 is a potent, biphenyl-containing RBM39 molecular glue degrader, shows potent antiproliferative activity with IC50 of 166 nM for HCT-116 cells.

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生物&药学活性

YSA64 is a potent, biphenyl-containing RBM39 molecular glue degrader, shows potent antiproliferative activity with IC50 of 166 nM for HCT-116 cells.
YSA64 robustly reduced RBM39 levels at 0.05 uM in HCT-116 cells.
YSA64 shows IC50 values of 125.3 nM and 111.7 nM in A673 and MV4-11 cells, respectively.
YSA64 administered orally at 100 or 200 mg/kg once daily (qd) for 10 days effectively suppressed tumor progression, yielding tumor growth inhibition value of 51.9% in SCID mice bearing MV4-11 subcutaneous xenografts.

物理化学性质&存储条件

分子量	460.55
分子式	C25H24N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-cyano-4-methyl-1H-indol-7-yl)-2'-(methoxymethyl)-4'-(methylamino)-[1,1'-biphenyl]-3-sulfonamide

参考文献

1. Xilin Lyu, et al. Eur J Med Chem. 2026 Sep 15:314:118921.

YSA64 (YSA-64)

生物&药学活性

物理化学性质&存储条件

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YSA64 (YSA-64)

生物&药学活性

物理化学性质&存储条件

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