KRAS G12D PROTAC VI-1

Chemical Structure : KRAS G12D PROTAC VI-1

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货号: PC-28654Not For Human Use, Lab Use Only.

KRAS G12D PROTAC VI-1 is a potent, selective KRAS G12D PROTAC degrader, exhibits anti-proliferative activity with IC50 of 4.27 uM (PANC-1).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KRAS G12D PROTAC VI-1 is a potent, selective KRAS G12D PROTAC degrader, exhibits anti-proliferative activity with IC50 of 4.27 uM (PANC-1).
VI-1 (10 uM) induces KRAS degradation of 69%, and 52% in PANC 0203, and SNU-1 cells respectively
VI-1 shows no significant effect on the degradation of KRAS G12D in other mutant cell lines such as PANC 0327 (G12V), A549 (G12S), NCl-H358 (G12C), or normal pancreatic tissue (HPNE)

物理化学性质&存储条件

分子量	1154.80
分子式	C61H69ClFN11O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R)-1-((2S)-2-(2-(2-(4-(3-((2R)-2-(((4-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yl)-7-(8-chloronaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)-3-oxopropyl)-1H-pyrazol-1-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Jiang L, et al. Eur J Pharm Sci. 2026 Nov 1;226:107633.