HBC-8 | MAP3K1 degrader | Probechem Biochemicals

Chemical Structure : HBC-8

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HBC-8 (HBC8)

货号: PC-28683Not For Human Use, Lab Use Only.

HBC-8 is a potent, selective CRBN-dependent MAP3K1 PROTAC degrader of 200 nM and 45 nM in T47D and NCIH1048, respectively, shows IC50 of 0.25 uM in HCT116 WT cells.

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生物&药学活性

HBC-8 is a potent, selective CRBN-dependent MAP3K1 PROTAC degrader of 200 nM and 45 nM in T47D and NCIH1048, respectively, shows IC50 of 0.25 uM in HCT116 WT cells.
HBC-8 induces its effects through ternary complex-mediated proteasomal degradation of MAP3K1 and perturbs corresponding downstream signaling.
HBC-8 inhibits T47D cells with IC50 of 2 nM in growth inhibition assay.
HBC-8 showed antitumor effects in an in vivo orthotopic ovarian cancer model without observable toxicity.

物理化学性质&存储条件

分子量	768.71
分子式	C37H31F3N10O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)-4-(3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ureido)-2-(trifluoromethyl)benzamide

参考文献

1. Umeta LT, et al. Mol Biomed. 2026 Oct 28;7(1):230.

HBC-8 (HBC8)

生物&药学活性

物理化学性质&存储条件

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HBC-8 (HBC8)

生物&药学活性

物理化学性质&存储条件

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