CB039 | RBM39 degrader | Probechem Biochemicals

Chemical Structure : CB039

CAS No.: 3056259-55-0

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CB039 (CB-039)

货号: PC-28649Not For Human Use, Lab Use Only.

CB039 is a potent RBM39 molecular glue degrader with cell growth inhibition IC50 of 36.7 nM against HCT-116 cells.

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10 mg	￥4780	In stock
25 mg	￥8580	In stock
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生物&药学活性

CB039 is a potent RBM39 molecular glue degrader with cell growth inhibition IC50 of 36.7 nM against HCT-116 cells.
CB039 facilitates RBM39 degradation through a CRL complex and a functional proteasome, similar to the actions of Indisulam.
CB039 enhances the recruitment of RBM39 to DCAF15 by extensive interactions.
CB039 significantly increases intron retention (RI) transcripts of CUL4A, NCKAP1L, and PRPF38A in HCT-116 cells, induces multiple RNA splicing defects.
CB039 induces CEP192 exon 42 skipping and reduced CEP192 protein levels.
CB039 demonstrated significant in vivo antitumor efficacy in HCT-116 mouse xenograft model.

物理化学性质&存储条件

分子量	481.53
分子式	C23H23N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)phenyl)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoacetamide

参考文献

1. Xilin Lyu, et al. J Med Chem. 2025 Apr 10;68(7):7807-7826.

CB039 (CB-039)

生物&药学活性

物理化学性质&存储条件

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CB039 (CB-039)

生物&药学活性

物理化学性质&存储条件

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