CW-3308 | BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : CW-3308

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CW-3308 (CW3308)

货号: PC-22939Not For Human Use, Lab Use Only.

CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line.

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生物&药学活性

CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line.
CW-3308 also effectively induced depletion of BRD9 protein in the HS-SY-II synovial sarcoma cell line in Western blotting analysis with DC50 < 10 nM and Dmax > 95%.
CW-3308 effectively inhibited cell growth in the G401 rhabdoid tumor cell line and the HS-SY-II synovial sarcoma cell line and is much more potent than BI-7273 in both cell lines.
CW-3308 50 mg/kg effectively depleted BRD9 in the tumor tissue by >90% at 3 h time point and by 45% at 24 h time point in the HS-SY-II synovial sarcoma xenograft tumor model.

物理化学性质&存储条件

分子量	800.91
分子式	C45H48N6O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-Dioxopiperidin-3-yl)-6-((3-(4-(2-ethyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxybenzoyl)-3-azaspiro[5.5]undecan-9-yl)methyl)-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione

参考文献

1. Changwei Wang, et al. J Med Chem. 2024 Aug 12. doi: 10.1021/acs.jmedchem.4c00971.

CW-3308 (CW3308)

生物&药学活性

物理化学性质&存储条件

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CW-3308 (CW3308)

生物&药学活性

物理化学性质&存储条件

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