INY-03-041

Chemical Structure : INY-03-041

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货号: PC-72497Not For Human Use, Lab Use Only.

INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN).

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生物&药学活性

INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN).
INY-03-041 exhibits more potent and prolonged effects on downstream signaling than GDC-0068.
INY-03-041 induced potent degradation of all three AKT isoforms in a dose-dependent manner after a 12-hour treatment, with maximal degradation observed between 100 to 250 nM.

物理化学性质&存储条件

分子量	798.426
分子式	C44H56ClN7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(10-(((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)decyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Inchul You, et al. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

INY-03-041

生物&药学活性

物理化学性质&存储条件

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INY-03-041

生物&药学活性

物理化学性质&存储条件

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