Vepdegestrant (ARV-471) | ER degrader | Probechem Biochemicals

Chemical Structure : ARV-471

CAS No.: 2229711-68-4

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ARV-471 (Vepdegestrant, ARV471)

货号: PC-72621Not For Human Use, Lab Use Only.

ARV-471 (Vepdegestrant) is an investigational orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) with DC50 of 1.8 nM.

规格	价格	库存
1 mg	￥1980	In stock
5 mg	￥4580	In stock
10 mg	￥7580	In stock
25 mg		Get quote

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生物&药学活性

ARV-471 (Vepdegestrant) is an investigational orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) with DC50 of 1.8 nM.
ARV-471 induces ER degradation in multiple ER+ breast cancer cell lines, including MCF-7 cells and ESR1-mutant lines, shows potential as both a single agent and in combination with CDK4/6 inhibitors, as well as superior inhibition of tumor growth compared to Fulvestrant.

物理化学性质&存储条件

分子量	723.379
分子式	C45H49N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (72.3 mg/mL)
Chemical Name/SMILES	(S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Lin X, et al. Eur J Med Chem. 2020 Nov 15;206:112689.

2. Wang C, et al. Eur J Med Chem. 2021 Dec 5;225:113749.

ARV-471 (Vepdegestrant, ARV471)

生物&药学活性

物理化学性质&存储条件

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ARV-471 (Vepdegestrant, ARV471)

生物&药学活性

物理化学性质&存储条件

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