GNE-987 | BET degrader | Probechem Biochemicals

Chemical Structure : GNE-987

CAS No.: 2417371-71-0

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货号: PC-72911Not For Human Use, Lab Use Only.

GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM.

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GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM.

分子量	1096.32
分子式	C56H67F2N9O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide

1. Thomas H Pillow, et al. ChemMedChem. 2020 Jan 7;15(1):17-25.