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首页-抗体药物偶连体和PROTACs-PROTAC-NSD2-LDD
NSD2-LDD

Chemical Structure : NSD2-LDD

CAS No.:

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NSD2-LDD

货号: PC-27158Not For Human Use, Lab Use Only.

NSD2-LDD is a cereblon-recruiting and PWWP1-mediated ligand directed degrader (LDD) of histone methyltransferase NSD2, selectively and potently eliminates full length and PWWP1 domain containing NSD2 protein isoforms, induces global loss of H3K36me2 and reverses the oncogenic program of t(4;14) multiple myeloma.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NSD2-LDD is a cereblon-recruiting and PWWP1-mediated ligand directed degrader (LDD) of histone methyltransferase NSD2, selectively and potently eliminates full length and PWWP1 domain containing NSD2 protein isoforms, induces global loss of H3K36me2 and reverses the oncogenic program of t(4;14) multiple myeloma.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Hu B, et al. Blood. 2026 Jun 29:blood.2025031998.

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