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首页-抗体药物偶连体和PROTACs-PROTAC-R4VP
R4VP

Chemical Structure : R4VP

CAS No.: 2839431-69-3

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R4VP (RNF4-VHL-Protac-like)

货号: PC-26979Not For Human Use, Lab Use Only.

R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells.

物理化学性质&存储条件

分子量 951.58
分子式 C51H59ClN6O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-(4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butyl)-N4-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)succinamide

参考文献

1. Oknin-Vaisman A, et al. Oncogene. 2026 Jun 5. doi: 10.1038/s41388-026-03829-2.

2. Carl C Ward, et al. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440.

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