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首页-抗体药物偶连体和PROTACs-PROTAC-NUCC-0227579
NUCC-0227579

Chemical Structure : NUCC-0227579

CAS No.:

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NUCC-0227579 (NUCC0227579, CD73 degrader C79)

货号: PC-27236Not For Human Use, Lab Use Only.

NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways.
C79 eliminated CD73 at the cell surface and intracellular compartments across multiple human cancer cell lines, abolishing nucleotidase activity and more effectively reversing adenosine-mediated immunosuppression than enzymatic inhibitors.
C79 enhanced NF-κB/NFAT signaling, increased IFN-γ and TNF-α production, and promoted human CD8+ T cell activation and proliferation.
C79 impaired tumor cell metabolic fitness, proliferation, migration, and adhesion through non-nucleotidase-dependent mechanisms.
C79 significantly suppressed tumor growth while enhancing antitumor immune responses humanized NSG mouse models of TNBC.

物理化学性质&存储条件

分子量 450.89
分子式 C24H15ClN8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((5-(4-chloro-1-(1H-indazol-6-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrazol-1-yl)methyl)benzonitrile

参考文献

1. Ping Xie, et al. J Med Chem. 2026 Jul 9;69(13):15630-15652.

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