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首页-抗体药物偶连体和PROTACs-PROTAC-XZ8078
XZ8078

Chemical Structure : XZ8078

CAS No.:

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XZ8078 (XZ-8078)

货号: PC-27235Not For Human Use, Lab Use Only.

XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM.
XZ8078 displays potent cell growth inhibitory activities against HR-proficient and clinically used PARPi-resistant cancer cells, with efficacy significantly superior to that of AZD5305.
XZ8078 demonstrates excellent tumor growth inhibition (TGI) in the AZD5305-sensitive/-insensitive xenograft model with TGI values of 133.6% and 71.9%, respectively.

物理化学性质&存储条件

分子量 840.92
分子式 C45H45FN10O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,6-dioxopiperidin-3-yl)-5-((R)-3-((4-((R)-7-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-5-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)piperidin-1-yl)methyl)pyrrolidin-1-yl)isoindoline-1,3-dione

参考文献

1. Xuetao Zhang, et al. J Med Chem. 2026 Jun 30. doi: 10.1021/acs.jmedchem.6c00239.

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