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首页-抗体药物偶连体和PROTACs-PROTAC-SK-3-91
SK-3-91

Chemical Structure : SK-3-91

CAS No.: 2769753-23-1

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SK-3-91

货号: PC-27299Not For Human Use, Lab Use Only.

SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes.

物理化学性质&存储条件

分子量 887.41
分子式 C42H47ClN10O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

参考文献

1. Donovan KA, et al. Cell. 2020 Dec 10;183(6):1714-1731.e10.

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