Cemsidomide (CFT7455) | IKZF1/3 degrader | Probechem Biochemicals

Chemical Structure : CFT7455

CAS No.: 2504233-68-3

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CFT7455 (Cemsidomide, CFT-7455)

货号: PC-73321Not For Human Use, Lab Use Only.

Cemsidomide (CFT7455) is a highly potent and selective degarder of IKZF1/3 with cereblon binding IC50 of 0.4 nM and picomolar DC50.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Cemsidomide (CFT7455) is a highly potent and selective degarder of IKZF1/3 with cereblon binding IC50 of 0.4 nM and picomolar DC50.
Treatment of the KiJK cell line of anaplastic large cell lymphoma (ALCL) with CFT7455 for 6 hours led to an 89% reduction in IKZF1 protein levels.
CFT7455 demonstrated potent antiproliferative activity across a panel of NHL cell lines with MYC, BCL2, and/or BCL6 translocations or rearrangements.
CFT7455 is an orally bioavailable.
CFT7455 achieved improved in vivo potency and efficacy, including deeper and more durable tumor regressions in models of ALCL, diffuse large B-cell lymphoma (DLBCL) and MCL in xenograft models.

物理化学性质&存储条件

分子量	469.541
分子式	C28H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-(6-{[4-(morpholin-4-ylmethyl)phenyl]methyl}-2-oxobenz[cd]indol-1(2H)-yl]piperidine-2,6-dione

CFT7455 (Cemsidomide, CFT-7455)

生物&药学活性

物理化学性质&存储条件

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CFT7455 (Cemsidomide, CFT-7455)

生物&药学活性

物理化学性质&存储条件

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