CRBN(BRAF)-24 | BRAF V600E PROTAC | Probechem Biochemicals

Chemical Structure : CRBN(BRAF)-24

加入收藏

CRBN(BRAF)-24 (BRAF V600E PROTAC)

货号: PC-38718Not For Human Use, Lab Use Only.

CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells.
CRBN(BRAF)-24 showed more potent and sustained suppression of MAPK signaling than a BRAFV600E inhibitor, PLX-8394, in BRAFV600E-driven cancer cells.
CRBN(BRAF)-24 induced neither BRAFWT degradation nor paradoxical activation of the MAPK pathway in BRAF wild-type cells.

物理化学性质&存储条件

分子量	1111.168
分子式	C53H57F3N12O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-N-(3-(5-(2-(4-(4-(1-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoyl)piperidin-4-yl)butanoyl)piperazin-1-yl)pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide

参考文献

1. Nobumichi Ohoka, et al. Cancer Sci. 2022 May 17. doi: 10.1111/cas.15401.