STING PROTAC SP23

Chemical Structure : STING PROTAC SP23

CAS No.: 2762552-74-7

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货号: PC-38566Not For Human Use, Lab Use Only.

SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
25 mg		Get quote

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生物&药学活性

SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.
SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.

物理化学性质&存储条件

分子量	699.677
分子式	C34H33N7O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-N4-(4-(5-nitrofuran-2-carboxamido)phenyl)fumaramide

参考文献

1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.