JCS-1 | DcpS PROTAC | Probechem Biochemicals

Chemical Structure : JCS-1

加入收藏

JCS-1 (DcpS PROTAC degrader)

货号: PC-47084Not For Human Use, Lab Use Only.

JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines.

物理化学性质&存储条件

分子量	1174.425
分子式	C62H79N9O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4R)-N-(2-((17-(3-((4-(((2,4-diaminoquinazolin-5-yl)oxy)methyl)piperidin-1-yl)methyl)phenoxy)-3,6,9,12,15-pentaoxaheptadecyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide

参考文献

1. Jake C Swartzel, et al. ACS Chem Biol. 2022 Jun 24. doi: 10.1021/acschembio.2c00145.

JCS-1 (DcpS PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JCS-1 (DcpS PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.