dBRD9-A | BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : dBRD9-A

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dBRD9-A (dBRD 9-A)

货号: PC-72322Not For Human Use, Lab Use Only.

dBRD9-A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

dBRD9-A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.
dBRD9-A blocks synovial sarcoma tumour progression and oncogenic transcription.
dBRD9-A limited IFN‐induced expression of certain ISGs in multiple cell types, significantly reduced induction of 29 ISGs, including many ISGs known to harbor antiviral activity against the viruses, such as MX1, MX2, IFITM1, IFITM3, IDO1, and BST2.

物理化学性质&存储条件

分子量	779.895
分子式	C42H49N7O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]-

参考文献

1. Gerard L Brien, et al. Elife. 2018 Nov 15;7:e41305.

2. Jacob Börold, et al. EMBO Rep. 2021 Oct 5;22(10):e52823.

dBRD9-A (dBRD 9-A)

生物&药学活性

物理化学性质&存储条件

参考文献

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dBRD9-A (dBRD 9-A)

生物&药学活性

物理化学性质&存储条件

参考文献

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