HPK1 PROTAC SS47 | HPK1 degrader | Probechem Biochemicals

Chemical Structure : HPK1 PROTAC SS47

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HPK1 PROTAC SS47 (HPK1 degrader SS47)

货号: PC-72308Not For Human Use, Lab Use Only.

HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.

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生物&药学活性

HPK1 PROTAC SS47 is a heterobifunctional small molecule HPK1 degrader based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.
SS47 exerts proteasome-mediated HPK1 degradation within 48 h of treatment, SS47 (100 nM) induced HPK1 degradation in bone-marrow-derived DCs, significantly increased the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ.
SS47 showed markedly better inhibition of tumor growth than either ZYF0033 or the ddH2O control in mice with subcutaneous 4T-1 tumors.

物理化学性质&存储条件

分子量	953.077
分子式	C49H56N6O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((15-(4-(5-(6-amino-5-((3-(3-hydroxy-3-methylbut-1-yn-1-yl)benzyl)oxy)pyridin-3-yl)thiazol-2-yl)piperidin-1-yl)-15-oxo-3,6,9,12-tetraoxapentadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Jingwen Si, et al. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

HPK1 PROTAC SS47 (HPK1 degrader SS47)

生物&药学活性

物理化学性质&存储条件

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HPK1 PROTAC SS47 (HPK1 degrader SS47)

生物&药学活性

物理化学性质&存储条件

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