MS1943 |CAS:2225938-17-8 Probechem Biochemicals

Chemical Structure : MS1943

CAS No.: 2225938-17-8

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MS1943 (MS-1943)

货号: PC-38300Not For Human Use, Lab Use Only.

MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
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生物&药学活性

MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
MS1943 is highly selective for EZH2 over a wide range of methyltransferases including EZH1, as well as 45 kinases.
MS1943 inhibited TNBC cells that express EZH2 (HCC1187, HCC70, BT549 and HCC1954, GI50s=1.1-4.9 uM), but not EZH2 inhibitors (GSK126, CPI-1205, EPZ6438 and C24).
MS1943 reduces EZH2 levels in cancer cells, suppresses tumor growth in vivo.

物理化学性质&存储条件

分子量	718.95
分子式	C42H54N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	6-(6-(4-(2-(2-((3r,5r,7r)-adamantan-1-yl)acetamido)ethyl)piperazin-1-yl)pyridin-3-yl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-indazole-4-carboxamide

参考文献

1. Anqi Ma, et al. Nat Chem Biol. 2020 Feb;16(2):214-222.

MS1943 (MS-1943)

生物&药学活性

物理化学性质&存储条件

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MS1943 (MS-1943)

生物&药学活性

物理化学性质&存储条件

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