CC-885 | GSPT1 PROTAC | Probechem Biochemicals

Chemical Structure : CC-885

CAS No.: 1010100-07-8

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CC-885 (CC 885, CC885)

货号: PC-60125Not For Human Use, Lab Use Only.

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.
The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1.
CC-885 promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.

物理化学性质&存储条件

分子量	440.9
分子式	C22H21ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 100 mM (44 mg/mL).
Chemical Name/SMILES	N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea

参考文献

1. Collins I, et al. Biochem J. 2017 Mar 15;474(7):1127-1147.

2. Matyskiela ME, et al. Nature. 2016 Jul 14;535(7611):252-7.

3. Hansen JD, et al. J Med Chem. 2017 Apr 13. doi: 10.1021/acs.jmedchem.6b01911.

CC-885 (CC 885, CC885)

生物&药学活性

物理化学性质&存储条件

参考文献

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CC-885 (CC 885, CC885)

生物&药学活性

物理化学性质&存储条件

参考文献

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