TBK1 PROTAC 1 |CAS:2052306-13-3 Probechem Biochemicals

Chemical Structure : TBK1 PROTAC 1

CAS No.: 2052306-13-3

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TBK1 PROTAC 1 (TBK1 PROTAC 3i)

货号: PC-60484Not For Human Use, Lab Use Only.

TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.

规格	价格	库存
1 mg	￥2580	In stock
5 mg	￥5580	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
TBK1 PROTAC 1 is a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells.

物理化学性质&存储条件

分子量	1093.193
分子式	C53H74BrN9O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-18-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Crew AP, et al. J Med Chem. 2017 Jul 10. doi: 10.1021/acs.jmedchem.7b00635.

TBK1 PROTAC 1 (TBK1 PROTAC 3i)

生物&药学活性

物理化学性质&存储条件

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TBK1 PROTAC 1 (TBK1 PROTAC 3i)

生物&药学活性

物理化学性质&存储条件

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