SNIPER(AR)-51 | Androgen Receptor degrader | ProbeChem Biochemicals

Chemical Structure : SNIPER(AR)-51

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SNIPER(AR)-51 (SNIPER AR-51)

货号: PC-70206Not For Human Use, Lab Use Only.

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.

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生物&药学活性

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.
SNIPER(AR)-51 induces proteasomal degradation of AR and shows effective protein knockdown activity.
SNIPER(AR)-51 inhibits AR-mediated gene expression and proliferation of androgen-dependent prostate cancer cells, and efficiently induces caspase activation and apoptosis in prostate cancer cells.

物理化学性质&存储条件

分子量	984.226
分子式	C55H65N7O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(2-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

参考文献

1. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.

SNIPER(AR)-51 (SNIPER AR-51)

生物&药学活性

物理化学性质&存储条件

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SNIPER(AR)-51 (SNIPER AR-51)

生物&药学活性

物理化学性质&存储条件

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