CM11, VHL degrader |CAS 2244684-49-7 Probechem Biochemicals

Chemical Structure : CM11

CAS No.: 2244684-49-7

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CM11 (homo-PROTAC CM11, VHL degrader CM11)

货号: PC-60127Not For Human Use, Lab Use Only.

CM11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

CM11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation.
CM11 induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.
CM11 is a novel chemical probe for selective VHL knockdown.

物理化学性质&存储条件

分子量	1179.456
分子式	C58H82N8O14S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N20-bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

参考文献

1. Maniaci C, et al. Nat Commun. 2017 Oct 10;8(1):830.

CM11 (homo-PROTAC CM11, VHL degrader CM11)

生物&药学活性

物理化学性质&存储条件

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CM11 (homo-PROTAC CM11, VHL degrader CM11)

生物&药学活性

物理化学性质&存储条件

参考文献

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