dBRD9 |CAS:2170679-45-3 Probechem Biochemicals

Chemical Structure : dBRD9

CAS No.: 2170679-45-3

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货号: PC-60126Not For Human Use, Lab Use Only.

dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.

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生物&药学活性

dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.

dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.

dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.

dBRD9 exhibits antiproliferative effects in human AML cell lines.

分子量	783.839
分子式	C40H45N7O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide

1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.