dTRIM24 | TRIM24 PROTAC | Probechem Biochemicals

Chemical Structure : dTRIM24

CAS No.: 2170695-14-2

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货号: PC-63217Not For Human Use, Lab Use Only.

dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay.

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dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay.

TRIM24 degradation via dTRIM24 depends on VHL and the proteasome.

dTRIM24 downregulates MYC target genes in AML cell lines, shows antiproliferative effect in acute leukemia.

dTRIM24 is a chemical probe useful for more thorough mechanistic interrogation of TRIM24 in human biology in subsequent research.

分子量	1113.312
分子式	C55H68N8O13S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1 -benzo[ ]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy- (4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamid

1. Gechijian LN, et al. Nat Chem Biol. 2018 Mar 5. doi: 10.1038/s41589-018-0010-y.