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首页-抗体药物偶连体和PROTACs-PROTAC-dAR-6-1
dAR-6-1

Chemical Structure : dAR-6-1

CAS No.: 3020769-95-0

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dAR-6-1

货号: PC-28641Not For Human Use, Lab Use Only.

dAR-6-1 is a potent androgen receptor (AR) PROTAC degrader with DC50 of 0.23 nM in hDPC (Dmax=90%) and 0.90 nM in LNCaP (Dmax=91%), induces hair regeneration in androgenetic alopecia (AGA) mouse model.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

dAR-6-1 is a potent androgen receptor (AR) PROTAC degrader with DC50 of 0.23 nM in hDPC (Dmax=90%) and 0.90 nM in LNCaP (Dmax=91%), induces hair regeneration in androgenetic alopecia (AGA) mouse model.

物理化学性质&存储条件

分子量 727.27
分子式 C37H43ClN10O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(6-(2,6-dioxopiperidin-3-yl)pyridazin-3-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide

参考文献

1. Xiao Wang, et al. J Med Chem. 2026 Jun 11;69(11):13028-13054.

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