PVD-06 | PTPN2 degrader | Probechem Biochemicals

Chemical Structure : PVD-06

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PVD-06 (PVD06)

货号: PC-28645Not For Human Use, Lab Use Only.

PVD-06 is a potent, subtype-selective PTPN2 (TCPTP) degrader with DC50 of 216 nM in Jurkat cells, >60-fold selectivity over PTP1B.

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生物&药学活性

PVD-06 is a potent, subtype-selective PTPN2 (TCPTP) degrader with DC50 of 216 nM in Jurkat cells, >60-fold selectivity over PTP1B.
PVD-06 shows no significant effect in the levels of 7 other representative PTPs: PTPN1 (PTP1B), PTPN6, PTPN7, PTPN9, PTPN11 (SHP-2), PTPN18, and PTPN23.
PVD-06 significantly amplifies B16F10 cell growth inhibition in a concentration-dependent manner in the presence of IFN-γ.
PVD-06 induces PTPN2 degradation in a ubiquitination- and proteasome-dependent manner.
PVD-06 efficiently promotes T cell activation and amplifies IFN-γ-mediated B16F10 cell growth inhibition.

物理化学性质&存储条件

分子量	1074.13
分子式	C48H55F4N9O11S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(6-(2-(4-(7-(1,1-dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-8-fluoro-6-hydroxynaphthalen-2-yl)-1H-pyrazol-1-yl)acetamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

参考文献

1. Hu L, et al. J Med Chem. 2023 Nov 23;66(22):15269-15287.

PVD-06 (PVD06)

生物&药学活性

物理化学性质&存储条件

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PVD-06 (PVD06)

生物&药学活性

物理化学性质&存储条件

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