DDX18 degrader M12

Chemical Structure : DDX18 degrader M12

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货号: PC-28638Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DDX18 degrader M12 is a molecular glue degrder of DDX18 that reprogrammes the E3 ligase DCAF11 to degrade DDX18, functions as a prodrug that is activated through glutathione S-transferase-mediated glutathionylation.
promotes the DCAF11-DDX18 interaction with EC50 of 1.76 uM.
M12 promotes DDX18 degradation via the CRL4DCAF11 complex.
Glutathionylation of M12 converts it into a functional molecular glue for DCAF11–DDX18.
M12 induces proximity of DDX18 and DCAF11 occurs only in the presence of M12, GST and GSH (EC50=385 nM).
M12 is a DCAF11-binding warhead for the development of PROTACs.

物理化学性质&存储条件

分子量	314.14
分子式	C14H10Cl2FNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dimethylphenyl 2,6-dichloro-5-fluoronicotinate

参考文献

1. Hojong Yoon, et al. Nature. 2026 Sep;657(8133):1045-1052.