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首页-抗体药物偶连体和PROTACs-PROTAC-HQY1480
HQY1480

Chemical Structure : HQY1480

CAS No.:

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HQY1480 (HQY-1480)

货号: PC-28565Not For Human Use, Lab Use Only.

HQY1480 is a potent, selective and next-generation EGFR-mutant PROTAC derived from BI-4020 with DC50 of 0.9 nM and 0.7 nM in Ba/F3LR/TM and Ba/F3LR/TM/CS cells, overcomes osimertinib resistance, targets EGFRL858R/T790M/C797S (LR/TM/CS) triple mutant, but not wild-type EGFR protein.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HQY1480 is a potent, selective and next-generation EGFR-mutant PROTAC derived from BI-4020 with DC50 of 0.9 nM and 0.7 nM in Ba/F3LR/TM and Ba/F3LR/TM/CS cells, overcomes osimertinib resistance, targets EGFRL858R/T790M/C797S (LR/TM/CS) triple mutant, but not wild-type EGFR protein.

物理化学性质&存储条件

分子量 839.01
分子式 C47H54N10O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC1=NC(C2=C(N(N=C2)C)OCCC[C@H](C3)C)=CC(C(/C=C4N3C(C=C5CN(CC6)CCN6CC7CN(C8=CC(CN(C9C(NC(CC9)=O)=O)C%10=O)=C%10C=C8)C7)=C(C=C5)N\4)=O)=C1

参考文献

1. Qinyang He, et al. J Med Chem. 2026 Oct 22;69(20):24219-24252.

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