NCP07 | ERα degrader | Probechem Biochemicals

Chemical Structure : NCP07

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NCP07 (NCP-07)

货号: PC-28640Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

NCP07 is a potent, ERα coactivator-binding site (CBS) targeting PROTAC degrader of ERα, degrades ERα and its mutants in breast cancer cells, significantly degrades ERα (DC50<10 uM) in MCF-7, T47D and ESR1 mutant breast cancer cells (MCF-7EGFR, MCF-7D538G and MCF-7Y537S).
NCP07 exhibits significant anti-proliferation activities in MCF-7 breast cancer cells with IC50 of 0.25 uM.
NCP07 inhibited proliferation (IC5=0.13-1.22 uM) in both wild-type and ESR1-mutated cell lines.
NCP07 can not only specifically bind to CBS followed by inducing the formation of ERα-NCP07-VHL ternary complex, but also induce apoptosis and cell cycle arrest in drug-resistant cells.

物理化学性质&存储条件

分子量	1121.32
分子式	C58H72N8O13S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-(4-(3-(2-hydroxyethoxy)-4-nitrobenzamido)-3-isobutoxybenzamido)-3-isobutoxybenzamido)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Jinsen Liang, et al. Eur J Med Chem. 2026 Nov 5:317:119113.

NCP07 (NCP-07)

生物&药学活性

物理化学性质&存储条件

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NCP07 (NCP-07)

生物&药学活性

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