KI-CDK9d-32 | CDK9 degrader | Probechem Biochemicals

Chemical Structure : KI-CDK9d-32

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KI-CDK9d-32 (CDK9 PROTAC)

货号: PC-22535Not For Human Use, Lab Use Only.

KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.

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生物&药学活性

KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels.
KI-CDK9d-32 significantly suppresses transcription of MYC in both a dose- and time dependent manner.
KI-CDK9d-32 represses canonical MYC pathways and leads to a destabilization of nucleolar homeostasis.
KI-CDK9d-32 has strong cytotoxic effects relative to the inhibitors used, but activity is limited in cells with high ABCB1 level.

物理化学性质&存储条件

分子量	703.85
分子式	C39H45N9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazin-1-yl)methyl)-N-((1R,3R)-3-((5-propylpyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)benzamide

参考文献

1. Mohammed A Toure, et al. bioRxiv. 2024 May 15:2024.05.14.593352.

KI-CDK9d-32 (CDK9 PROTAC)

生物&药学活性

物理化学性质&存储条件

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KI-CDK9d-32 (CDK9 PROTAC)

生物&药学活性

物理化学性质&存储条件

参考文献

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