dWIZ-2 | WIZ degrader | Probechem Biochemicals

Chemical Structure : dWIZ-2

CAS No.: 2654011-51-3

加入收藏

dWIZ-2 (WIZ degrader)

货号: PC-22586Not For Human Use, Lab Use Only.

dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-2 increases CRBN-WIZ association.
dWIZ-2 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).
dWIZ-2 potently degraded WIZ in primary human erythroblasts in vitro.
dWIZ-2 (10 uM) increases both the percentage of HbF-expressing cells as well as total HbF in SCD-derived erythroblasts.
dWIZ-2 (30-100 mg/kg) is well tolerated and induced HbF in humanized mice and cynomolgus monkeys.

物理化学性质&存储条件

分子量	385.46
分子式	C21H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(((R)-1-ethylpiperidin-2-yl)methoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99

dWIZ-2 (WIZ degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

dWIZ-2 (WIZ degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.