Nek2 inhibitor V8

Chemical Structure : Nek2 inhibitor V8

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货号: PC-20888Not For Human Use, Lab Use Only.

Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Nek2 inhibitor V8 is a novel spirocyclic selective, reversible inhibitor of NIMA Related Kinase 2 (Nek2) kinase with IC50 of 2.4 uM, attenuates pAkt/PI3K signaling.
Nek2 inhibitor V8 attenuates proliferative and migratory phenotypes of highly aggressive human MDA-MB-231 breast and A549 lung cancer cell lines.

物理化学性质&存储条件

分子量	386.26
分子式	C14H16BrN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1NC2(CCN(S(=O)(C)=O)CC2)N=C1C3=CC=C(Br)C=C3

参考文献

1. Bhuiyan AI, et al. Bioorg Med Chem Lett. 2023 May 15;88:129288.