TAI-1 |CAS:1334921-03-7 Probechem Biochemicals

Chemical Structure : TAI-1

CAS No.: 1334921-03-7

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TAI-1 (TAI1;Hec1 inhibitor HAI-1)

货号: PC-61481Not For Human Use, Lab Use Only.

TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).
TAI-1 displays 1,000 times improvement in potency compared to INH1, shows nM levels for the majority of the NCI-60 panel.
TAI-1 targets the Hec1-Nek2 pathway, induces chromosomal misalignment and apoptosis, effectively inhibits tumor growth in multiple cancer xenograft models.

物理化学性质&存储条件

分子量	431.51
分子式	C24H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

参考文献

1. Huang LY, et al. J Exp Clin Cancer Res. 2014 Jan 9;33:6.

TAI-1 (TAI1;Hec1 inhibitor HAI-1)

生物&药学活性

物理化学性质&存储条件

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TAI-1 (TAI1;Hec1 inhibitor HAI-1)

生物&药学活性

物理化学性质&存储条件

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