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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-61266

KKL-40

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-61265

KKL-10

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-70355

VU0038882

S. aureus HssRS activator

VU0038882 is a small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism.
PC-70354

KKL-35

Antibacterial

KKL-35 is a small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity, inhibits the trans-translation tagging reaction with an IC50 of 0.9 uM.
PC-70348

TCA1

DprE1 inhibitor

TCA1 is a small molecule with activity against drug-resistant and persistent tuberculosis, inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
PC-70341

DSM 74

Pf DHODH inhibitor

DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
PC-70340

Genz 669178

Pf DHODH inhibitor

Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
PC-70339

IDI-6273

Pf DHODH inhibitor

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
PC-70327

S.aureus sortase inhibitor 6e

S.aureus sortase inhibitor

Sortase-IN-6e is a small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.
PC-70301

Negamycin

Antibiotic

Negamycin is a dipeptide antibiotic that inhibits the initiation of protein synthesis.
PC-61005

GSK951A

EchA6 inhibitor

GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.
PC-61004

GSK-729

EchA6 inhibitor

GSK-729 (GSK729) is a potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.

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