Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-62126	ML406 Mtb bioA inhibitor	ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.
PC-62035	J8-C8 acyl-HSL synthase TofI inhibitor	J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production.
PC-62027	CCG-102487 Streptokinase inhibitor	CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth.
PC-62026	CCG-2979 Streptokinase inhibitor	CCG 2979 is a small molecule inhibitor of gene expression of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor.
PC-61972	Enmetazobactam β-lactamase inhibitor	Enmetazobactam (AAI-101) is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.
PC-61943	CB-618 sodium β-lactamase inhibitor	CB-618 sodium (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates.
PC-61942	CB-618 β-lactamase inhibitor	CB-618 (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates.
PC-61940	GSK-229423 Bacterial DNA gyrase inhibitor	GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
PC-61939	NXL101 Bacterial DNA gyrase inhibitor	NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains.
PC-61938	Gepotidacin Bacterial Topo II inhibitor	Gepotidacin (GSK2140944) is a novel potent, selective bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens, including Gram-positive pathogens and MRSA.
PC-61937	LN-1-255 Beta-lactamase inhibitor	LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor.
PC-61930	Beauvericin Antibacterial	Beauvericin is a cyclic hexadepsipeptide with antibiotic and insecticidal effects, shows activity against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals.

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