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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-61751

AU-1235

MmpL3 inhibitor

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor with MIC of 0.1 ug/mL (0.3 uM) against Mtb H37Rv..
PC-61750

MmpL3 inhibitor C215

MmpL3 inhibitor

C215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3) with MIC90 of 16 uM against M. tuberculosis.
PC-61436

CRS3123

MetRS inhibitor

CRS3123 (REP 3123) is a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases (MetRS) in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
PC-61388

Macozinone

DprE1 inhibitor

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PC-61371

Contezolid

Antibiotic

Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
PC-61295

Murepavadin

Antibiotic, MRGPRX2 agonist

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.
PC-61266

KKL-40

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-61265

KKL-10

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
PC-70355

VU0038882

S. aureus HssRS activator

VU0038882 is a small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism.
PC-70354

KKL-35

Antibacterial

KKL-35 is a small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity, inhibits the trans-translation tagging reaction with an IC50 of 0.9 uM.
PC-70348

TCA1

DprE1 inhibitor

TCA1 is a small molecule with activity against drug-resistant and persistent tuberculosis, inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
PC-70341

DSM 74

Pf DHODH inhibitor

DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.

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