Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-72426	MAC-545496 GraR inhibitor	MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
PC-72420	KYT-1 Arg-gingipain inhibitor	KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).
PC-72419	KYT-36 gingipain K inhibitor	KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.
PC-72417	COR388 Lysine-gingipain inhibitor	COR388 (Atuzaginstat) is an orally bioavailable, brain penetrant small-molecule that irreversibly inhibits lysine-gingipain (Kgp) with Ki of <0.01 nM.
PC-72410	FIM1033 FimH inhibitor	FIM1033 (FIM-1033) is a potent small-molecule inhibitor of FimH with HAI EC90 of 8 nM, with antibiotica activities, significantly attenuated bacterial loads in pyelonephritis in treated mice.
PC-72404	Compound 11726148 Mtb Cyt bc1 inhibitor	Compound 11726148 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.05 ug/mL, targets cytochrome bc1 complex.
PC-72403	Compound 11626252 Mtb Cyt bc1 inhibitor	Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.
PC-72375	FG-944 LpxC inhibitor	FG944 (FG-944) is a potent selective LpxC inhibitor with MIC50 of 0.5 ug/mL against K.pneumoniae, synergizes with rifampin in carbapenem resistant K. pneumoniae and E. coli.
PC-72135	UAMC-03011 Anti-trypanosomal	UAMC-03011 is a potent anti-trypanosomal compound (IC50=0.63 uM, T. brucei).
PC-72087	MRL-494 BamA inhibitor	MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
PC-72065	Fobrepodacin Bacterial DNA gyrase inhibitor	Fobrepodacin (SR720) is the prodrof form of SPR719, mycobacterial DNA gyrase inhibitor.
PC-72064	SPR719 Bacterial DNA gyrase inhibitor	SPR719 (SPR 719) is a novel mycobacterial DNA gyrase inhibitor with bactericidal properties, inhibits M. abscessu with MIC 0.6 uM (abscessus ATCC 19977).

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