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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-72403

Compound 11626252

Mtb Cyt bc1 inhibitor

Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.
PC-72375

FG-944

LpxC inhibitor

FG944 (FG-944) is a potent selective LpxC inhibitor with MIC50 of 0.5 ug/mL against K.pneumoniae, synergizes with rifampin in carbapenem resistant K. pneumoniae and E. coli.
PC-72135

UAMC-03011

Anti-trypanosomal

UAMC-03011 is a potent anti-trypanosomal compound (IC50=0.63 uM, T. brucei).
PC-72087

MRL-494

BamA inhibitor

MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
PC-72065

Fobrepodacin

Bacterial DNA gyrase inhibitor

Fobrepodacin (SR720) is the prodrof form of SPR719, mycobacterial DNA gyrase inhibitor.
PC-72064

SPR719

Bacterial DNA gyrase inhibitor

SPR719 (SPR 719) is a novel mycobacterial DNA gyrase inhibitor with bactericidal properties, inhibits M. abscessu with MIC 0.6 uM (abscessus ATCC 19977).
PC-72063

MMV688844

Bacterial DNA gyrase inhibitor

MMV688844 (MMV844) is a piperidine-4-carboxamide with bactericidal properties against M. abscessus, targets DNA gyrase.
PC-72027

Antimicrobial peptide BING

cpxR inhibitor

Antimicrobial peptide BING (IRIILRAQGALKI) is a thermostable 13-residue peptide that targets bacterial envelope stress response by suppressing cpxR expression in Gram-negative bacteria.
PC-38335

BLI-489

Beta-lactamase inhibitor

BLI-489 is a bicyclic penem inhibitor that inhibits class A, C, and D beta-lactamases with synergistic effects with piperacillin.
PC-38313

KBP-7072

Tetracycline antibiotic

Zifanocycline (KBP-7072) is a potent, broad-spectrum, third-generation tetracycline antibacterial.
PC-38312

LPXC-516

LpxC inhibitor

LPXC-516 is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC), shows potency against the P. aeruginosa isolates with MIC90 of 2 ug/mL.
PC-38311

ACHN-975

LpxC inhibitor

ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).

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