LpxC-IN-5

Chemical Structure : LpxC-IN-5

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货号: PC-38420Not For Human Use, Lab Use Only.

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with IC50 of 20 nM, shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 ug/mL, respectively.

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生物&药学活性

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with IC50 of 20 nM, shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 ug/mL, respectively.

物理化学性质&存储条件

分子量	412.44
分子式	C21H24N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Propanediol, 2-amino-2-[[4-[2-[3-[[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]methyl]-5-isoxazolyl]ethynyl]phenoxy]methyl]-

参考文献

1. Yamada Y, et al. J Med Chem. 2020;10.1021/acs.jmedchem.0c01215.

LpxC-IN-5

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物理化学性质&存储条件

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LpxC-IN-5

生物&药学活性

物理化学性质&存储条件

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