Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-25324	LPC-058 LpxC inhibitor	LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.
PC-25241	Ganfeborole hydrochloride Mtb LeuRS inhibitor	Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-25240	DDD02049209 Mtb LysRS inhibitor	DDD02049209 is a potent, specific inhibitor of M. tuberculosis lysyl-tRNA synthetase (LysRS) with IC50 of 0.05 uM, inhibits M. tuberculosis phenotypic growth in culture (MIC) with 0.08 uM.
PC-25226	Polymyxin B Antibiotic	Polymyxin B is an antibiotic that inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity, neutralizes the effect of endotoxin and induces bacterial death by increasing its permeability.
PC-25221	CMX410 Mtb Pks13 inhibitor	CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM.
PC-25155	TXH1033 FtsZ inhibitor	TXH1033 is the orally active, carboxamide prodrug of TXH9179, which is a next-generation benzamide-based FtsZ inhibitor, TXH1033 is rapidly hydrolyzed to TXH9179 by serum acetylcholinesterases, exhibited in vivo efficacyin mouse model of systemic (peritonitis) MRSA infection.
PC-25154	TXH9179 FtsZ inhibitor	TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL.
PC-25152	UCM53 FtsZ inhibitor	UCM53 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 1.3 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 13 uM.
PC-25151	UCM05 FtsZ inhibitor	UCM05 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 43 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 100 uM, also is a fatty acid synthase (FASN) inhibitor wiht activity against HER2+ breast cancer.
PC-25079	Bacterial SPase inhibitor MD3 LepB inhibitor	Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.
PC-25078	Pezulepistat LepB inhibitor	Pezulepistat (Compound II) is a potent, selective inhibitor of bacterial type 1 signal peptidase LepB, shows serum MIC value of 0.5 μM against E. coli 25922, exhibits broad spectrum antibiotic activity.
PC-25077	Mtb LepB inhibitor 17af LepB inhibitor	Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.

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