| Cat. No. |
Product Name |
Information |
| PC-22567 |
OXF-077
Antibacterial agent
|
OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA. |
| PC-22557 |
Ciprofloxacin
Antibiotic
|
Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor and fluoroquinolone antibiotic, induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. |
| PC-22556 |
LEI-800
Bacterial DNA gyrase inhibitor
|
LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM. |
| PC-22548 |
D8-03
Francisella tularensis inhibitor
|
D8-03 is a potent inhibitor of intracellular growth of Francisella tularensis with IC50 of 15 nM in CFU assays, MIC50 value of 0.39 uM. |
| PC-22508 |
ECIN (E. coli inhibitor)
UPEC inhibitor
|
ECIN (E. coli inhibitor) is a copper-responsive small molecule inhibitor of wild-type uropathogenic Escherichia coli (UPEC) strains with IC50 of 336 ng/mL in the absence of copper, and 260 and 128 ng/mL in the presence of 25 and 250 µM copper, respectively. |
| PC-22507 |
A16B1
Salmonella PhoP/PhoQ inhibitor
|
A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity. |
| PC-22472 |
BTZ043
DprE1 inhibitor
|
BTZ043 is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. |
| PC-22350 |
Cadazolid
Antibiotic
|
Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057. |
| PC-22242 |
Pneumolysin inhibitor PB-3
Pneumolysin inhibitor
|
Pneumolysin inhibitor PB-3 is a specific small molecule inhibitor (pore-blocker) of pneumolysin (PLY), binds to Cys428 adjacent to the cholesterol recognition domain of PLY with KD of 256 nM, block the PLY-induced hemoglobin release in sheep erythrocytes with IC50 of 3.1 uM. |
| PC-22210 |
Cerastecin D
MsbA inhibitor
|
Cerastecin D is a potent small molecule inhibitor of A. baumannii transporter MsbA, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
| PC-22209 |
Cerastecin C
MsbA inhibitor
|
Cerastecin C is a potent small molecule inhibitor of A. baumannii transporter MsbA, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
| PC-22208 |
Cerastecin B
MsbA inhibitor
|
Cerastecin B is a potent small molecule inhibitor of A. baumannii transporter MsbA with binding KD of 0.37 nM, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
